| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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Doxycycline Hyclate is a semi synthetic tetracycline antibiotic, which can penetrate the cell membrane and bind to the 30S ribosome subunit, interfere with the tRNA/mRNA interaction, and ultimately inhibit protein synthesis. As a broad-spectrum antibiotic and antibacterial agent, has strong resistance to bacteria that cause respiratory infections, including Mycoplasma pneumoniae and Haemophilus influenzae. In addition, it can also treat infections caused by Chlamydia, Rickettsia, and certain spirochetes, and has antigenic and insecticidal properties.
| Items | Specifications | Results |
| Appearance | Yellow crystalline powder | Conforms |
| Identification | TLC | Conforms |
| sulphuric acid reaction a yellow colour develops | Conforms | |
| it gives reaction of chlorides | Conforms | |
| PH | 2.0~3.0 | 2.3 |
| Specific absorbance | at 349nm e(1%) 300~355 | 320 |
| Specific optical rotation | -105 ~ -120° | -110° |
| Heavy metals: | ≤50ppm | < 20ppm |
| Light-absorbing impurities | at 490nm ≤0.07 | 0.03 |
| Related substances | 6-epidoxycycline ≤2.0% | 1.60% |
| metacycline ≤2.0% | 0.10% | |
| 4-epidoxycycline ≤0.5% (ep5) | Not found | |
| 4-epi-6-epidoxycycline ≤0.5% (ep5) | Not found | |
| oxytetracycline ≤0.5% (ep5) | Not found | |
| any other impurity ≤0.5% | Not found | |
| not identified impurities ≤0.1% (ep5) | Not found | |
| Ethanol | 4.3~6.0% (m/m) | 4.50% |
| Sulphated ash | ≤0.4% | 0.05% |
| Water | 1.4~2.8% | 1.80% |
| Assay | 95.0~102.0% ( c22h25cln2o8) | 98.60% |
| based on anhydrous, ethanol-free substance |
It is very effective in curing the upper respiratory tract infection, lacunar angina, infection of biliary tract, adenolymphitis, phlegmon, Chronic bronchitis caused by gram-positive cocci and gram-negative bacilli.
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