| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml). It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 μg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively. In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia. Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%. Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.
Marbofloxacin Specification
| Item | Specification | Result |
| Character | Light yellow, crystalline powder | Complies |
| Slightly soluble in water, sparing soluble or slightly soluble in methylene chloride, very slightly soluble in ethanol. | Complies | |
| Identification | IR spectra is consistent with CRS. | Complies |
| Absorbance | ≤0.20 | 0.08 |
| Related substance | Impurity A ≤0.1% | Not detected |
| Impurity B ≤0.1% | Not detected | |
| Impurity C ≤0.2% | 0.09% | |
| Impurity D ≤0.2% | Not detected | |
| Impurity E ≤0.2% | Not detected | |
| Any other impurities ≤ 0.2% | Not detected | |
| Total impurities ≤0.5% | 0.09% | |
| Loss on drying | ≤0.5% | 0.06% |
| Sulphated ash | ≤0.1 | 0.05% |
| Heavy metals | ≤20ppm | <20ppm |
| Assay | 99.0%-101.0% on anhydrous basis | 99.7% |
Mabofloxacin is a novel fluoroquinolone antimicrobial agent, which inhibits the growth of bacteria by inhibiting the DNA transcriptase of bacteria, and has antimicrobial effect on Gram-negative bacteria, Gram-positive bacteria and mycoplasma.
Mabofloxacin can be well absorbed by oral administration and injection, and its toxic and side effects are low.
Mabofloxacin is used for respiratory tract, digestive tract, urinary tract and skin infections caused by sensitive bacteria in cattle, pigs, dogs and cats. It is also effective for bovine and sheep mastitis and porcine mastitis - uteritis - agalactia syndrome.
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